You cannot save during combat

Xiviriel

Just so you know, you cannot save during combat.

Teflon

And during conversation too. Which sucks.

kilroy_was_here

You also cannot save when ongoing area effects are active. (Web, Stinking Cloud etc) Even if they are not within your line-of-sight you cannot save on that map until the duration expires.

Darkcloud

You also cannot save when you don't have control over your party members.

Splod

You also cannot save when your party is scattered...

Awong124

You also can't save on the map where you get waylaid by enemies.

Space_hamster

The best time to save is right when you enter a new map.

PawnSlayer

You cannot save while a party member is leaving the map (i.e. after they've finished speaking with you).

kilroy_was_here

Once Tiax rules, none will be saved except through him!

reedmilfam

You also cannot save if your hamster is trapped in a den of steeinking evil.