So I touched on this in another thread, but I figured I'd make an official thread, as I feel it's worthy of its own.
Constant saving and reloading has always been an issue in infinity engine games. To make the player need to be much more careful, and to help introduce a better risk/reward system I would propose the following optional mode:
If playing in said mode, In order for the player to create a permanent save file, they must be in a designated safe area - a town, or inn for example.
If the player is in the wilderness, or in a dungeon, the player cannot create a permanent save file - instead they can only create a temporary one. If you've ever played Majora's Mask, you will easily understand this concept, as it would work in a similar way as the owl statues in MM. When a player saves his or her game in a non-safe area, it forces the player to quit out to the menu. If the player loads that game, it automatically deletes itself. This prevents the player from being able to reload his or her game over and over in a dangerous area, but still allows the player to quit playing and come back later. Again, permanent save files would only be able to be created in designated safe areas.
The only problem I see with this, is that with the current save file system, the player could easily copy/paste their temporary dungeon save files if they wanted to cheat the mode. Should such a mode be created, I'll leave it to the programmers to figure out how to prevent this!