Icewind Dale 1 and 2 had the overarching plot of Auril and her followers attempting to snuff out the warmth and the (un)natural growth of the Kuldahar Tree and the Ten-Towns. Though they are not the main antagonists (or maybe they are), they were always somewhat connected to the Spine of the World.
In Sword Coast Adventurer's Guide, it was mentioned that "In 1485, in Icewind Dale, the Chosen of Auril foments
war with Ten-Towns and was defeated." And our game was set at 1281DR (IWD1) and 1301DR (IWD2). The Aurilites have been plotting for hundreds of years! (Provided IWD1&2 are canon, even though they may not be so)
I've always loved the bits and pieces of lore that somewhat connected to Icewind Dale (whether they are canon or not). I personally want IWD2: EE and/or IWD3+ to happen, but knowing that they won't, in every D&D Pen & Paper campaigns set in Forgotten Realms that I have attended and plan to attend, my characters are often from the Ten-Towns and have some kind of personal quest regarding the Ten-Towns.
Please share any of the stories/campaigns/characters you have done (video gaming or PNP) that somewhat connects him/her/itself to Icewind Dale whether it was a footnote or a full-blown ambition of some kind, even your thoughts on the events that had transpired in IWD1 and 2 are welcomed here!