I never have any trouble with Tarnesh, thanks to a well-timed use of the wand of magic missiles. He is very squishy if his mirror image spell gets disrupted, and I also usually have Xzar and Montaron to help gang up on him.
Neira on another hand usually gives me trouble. Disrupting ALL of her spells can be difficult, and one successful cast will mean a party wipe if I am unlucky.
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My personal favorite assassin line is Tarnesh's "Hi friend." It's totally burned into my memory.
Neira on another hand usually gives me trouble. Disrupting ALL of her spells can be difficult, and one successful cast will mean a party wipe if I am unlucky.