I just abandoned a BGEE run when my characters were all at 5th level because I decided I don't like the BG2 weapon proficiency system. It seems daft that someone who can use a long sword doesn't know how to use a bastard sword. So I used the tweaks anthology to bring back the BG1 system (but kept the fighting styles because I like doing more damage) and then headed back to Candlekeep for the umpteenth time.
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I guess that would be my reason to restart.