So, stealing from a BBC show which most people here will have probably never heard of, the idea here is to make a list of things you have never seen/read/partook in, even though they are really popular and everyone else always talks about them. Any kind of pop-cultural phenomenon that for whatever reason you've stayed out of.
So, there are two really big game franchises that I have never played.
The first is Final Fantasy. Years ago I saw my friend playing one the SNES/Famicom, but I've just never been interested in them. I have played several other JRPG's, like the Tales Of series and even Star Ocean because someone gave it to me when I got my Xbox 360... but yeah, I don't know why but the Final Fantasy games just never appealed to me. I've seen pictures, and maybe it's just that the character designs don't appeal to me.
The second is Tomb Raider. Never even seen the movies. Since the original game was released there was a lot of fuss about Lara's polygons and how 'hawt' they are, but honestly... I just don't think she's that attractive, and that and all the other hype surrounding actually just buts me off ever wanting to play them. I might possibly give the new one a try since it's written by Rhianna Pratchett and maybe I'll finally be able to take Lara seriously as an actual tomb raider.
For movies... it's hard to think of any major ones I've never seen. But probably the biggest in it's day that I haven't watched, at least not all the way through, is The Blair Witch Project. And the reason is actually quite silly and petty. See, back in the day, I edited several films. I packed that in because I never got paid anything I was promised by the people I worked with (and if you want to know what happened to any of those films... well, you'd have more chance of finding The Day the Clown Cried than any of those). But anyway, I had the revolutionary idea of making an alien invasion/war of the worlds type of movie, but, all told through found camcorder footage after the event and you would mostly just see alien war machines in the distance blowing stuff up while our characters are running away. But, while my idea was pooh-poohed, what should come out shortly after? The Blair Witch Project. And since then a string of found footage movies that I've grown to hate. I mean, this was back when camcorders were becoming more affordable and so it was probably natural that many people around the world were thinking along those lines. So I was bitter at the time. Now I think I probably should watch it, and maybe I'll even enjoy it.
For books... well I've never read Harry Potter. Being older when they came out and not having kids of my own, I've never felt that I was the target audience for them. I have seen the films though.
And TV... well there are lots of shows I've never watched. Never seen Big Brother, or X-Factor or Pop Idol or whatever... reality TV never really appeals to me. These days I mostly watch comedies or documentaries on TV, and there are a lot of much hyped shows I've never watched. Dexter, Breaking Bad, Lost, Deadwood, Supernatural, Arrow... to name a few. The reason is that when I start getting into something I can't stop, I have to see it all the way through, so particularly if I'm coming in late to something I need to set aside a lot of time to do it.